Skin Cancer

Basal Cell Carcinoma (BCC)

Overview

Name

Basal Cell Carcinoma (BCC)

Type

Skin Cancer

Basal cell carcinoma (BCC) is the most common form of skin cancer, and additionally, is the most common cancer diagnosed in the U.S. Current estimates are that over four million cases occur annually in the U.S. Basal cells are found at the lower part (base) of the epidermis (the upper layer of the skin); hence the name “basal cell carcinoma.” Due to its location on the skin surface, the epidermal cell layer is easily penetrated by UV light. When UV enters cells, the DNA can be damaged, leading to abnormal cell function and potentially to cancer formation. Hence, these skin cancers are associated with sun exposure and use of UV indoor tanning devices. BCCs are frequently observed on sun-exposed areas of skin, such as the face, scalp (especially in balding individuals), ears, neck, hands, arms and legs, and back. Sun damage increases one’s risk of developing BCC.

 

Basal cell carcinomas may appear as pearly, pink or reddish, semi-translucent bumps on the skin, or sometimes as donut-shaped raised growths with scabbing or oozing in the center. Tiny blood vessels may be visible within the cancer. Other BCCs may be more eczema-like, with redness, scaling and often a raised, rolled or thread-like border. Rarely, BCCs may appear as waxy or shiny, barely raised, scar-like sheets on the skin surface. In individuals with darker skin, part or all of a BCC may appear pigmented (brown). Although not usually painful, BCCs may easily bleed, itch, and have a tendency not to heal. BCCs tend to be slow growing and are both more treatable and less likely to invade other tissues than melanoma. However, left untreated, BCCs may eventually invade deeper into the skin and underlying tissues, causing disfigurement. Life threatening BCCs are rare but do occur.

 

Less common risk factors for BCC include severe scarring (such as those from burns, especially scars of long duration), chronic inflammation (such as skin ulcers), radiation exposure (such as X-ray treatment for acne) and arsenic exposure (such as drinking well water contaminated with arsenic).

 

Like other skin cancers, BCCs can develop anywhere on the skin surface.  New or unusual skins growths should be brought to the attention of your dermatologist.

 

All photographs and diagrams are intended for informational purposes only and are not intended to be used for diagnosis.  A dermatologist should be consulted for examination and diagnosis of skin lesions.

Images

A diagram of the skin epidermis. The blue arrow on the left points to the thin layer of basal cells, which in this diagram are depicted as white, rectangular-shaped cells. When basal cells become cancerous, they give rise to a basal cell carcinoma.
A diagram of the skin epidermis. The blue arrow on the left points to the thin layer of basal cells, which in this diagram are depicted as white, rectangular-shaped cells. When basal cells become cancerous, they give rise to a basal cell carcinoma.
Superficial Basal Cell Carcinoma. This type of BCC looks like eczema but note the translucent-appearing raised bumps (arrow) on the border of the cancer.
Superficial Basal Cell Carcinoma. This type of BCC looks like eczema but note the translucent-appearing raised bumps (arrow) on the border of the cancer.
Superficial Basal Cell Carcinoma (photo courtesy of Kelly Nelson, MD, nci-vol-9236-72)
Superficial Basal Cell Carcinoma. Photo courtesy of Kelly Nelson, MD, nci-vol-9236-72
BCC on the side of the nose. This BCC is donut-shaped with firm outer margins and a central depression or indentation.
Basal Cell Carcinoma on the side of the nose. This BCC is donut-shaped with firm outer margins and a central depression or indentation.
BCC which is more easily felt than seen. Note the central indentation of this donut-shaped BCC and the raised, shiny border.
BCC which is more easily felt than seen. Note the central indentation of this donut-shaped BCC and the raised, shiny border.
Nodular BCC on the nose (circled). This firm lesion appears semi-translucent (almost transparent), such that a few tiny blood vessels can be seen within the tumor.
Nodular BCC on the nose (circled). This firm lesion appears semi-translucent (almost transparent), such that a few tiny blood vessels can be seen within the tumor.
A nodular BCC with a central scab-filled depression. Note the raised, shiny, semi-translucent outer border.
A nodular BCC with a central scab-filled depression. Note the raised, shiny, semi-translucent outer border.
Pigmented BCC on the cheek. This BCC consists of a cluster of raised bumps that are semi-translucent or pearly appearing, some of which have distinct brown dots (melanin pigment).
Pigmented BCC on the cheek. This BCC consists of a cluster of raised bumps that are semi-translucent or pearly appearing, some of which have distinct brown dots (melanin pigment).
This is a photograph of a skin biopsy which confirmed a basal cell carcinoma. In a biopsy, a small section of skin is taken and viewed under the microscope by an MD pathologist. The black arrows point to two large nests of basal cells which have become cancerous, resulting in a basal cell carcinoma. The surface of the skin is at the top of the photo. The blue/green ink marks the lower surface of this shave biopsy.
This is a photograph of a skin biopsy which confirmed a basal cell carcinoma. In a biopsy, a small section of skin is taken and viewed under the microscope by an MD pathologist. The black arrows point to two large nests of basal cells which have become cancerous, resulting in a basal cell carcinoma. The surface of the skin is at the top of the photo. The blue/green ink marks the lower surface of this shave biopsy.
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Squamous Cell Carcinoma (SCC)